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张杰

科室:

职务:

职称:教授,博士生导师

擅长:

张杰

1978年4月3日生,现就职于厦门大学医学院,厦门大学特聘教授,博士生导师

主要荣誉:国家杰出青年科学基金,国家优秀青年科学基金,教育部新世纪优秀人才,福建省杰出青年基金,福建省青年拔尖人才,福建省高等学校新世纪优秀人才,厦门市五四青年奖章,厦门大学特聘教授,厦门大学南强青年拔尖人才

教育工作经历:

l1997年9月-2001年7月,四川大学,生命科学学院,学士

l2001年9月-2006年7月,中国科学院生物物理研究所,博士

l2006年9月-2009年6月,美国新泽西州立大学,细胞与神经科学学系,博士后

l2009年6月-2011年8月,美国新泽西州立大学,细胞与神经科学学系,研究助理

l2011年8月-至今,厦门大学医学院,教授,博士生导师

研究工作简介

张杰博士长期从事重大神经系统疾病(老年痴呆、抑郁症、自闭症、术后认知障碍)等的发病机制和药物开发研究。至今以第一作者或者通讯作者在国际知名期刊发表研究论文20余篇,平均影响因子7.8,H-index 17。其中回国独立开展研究工作以后,作为通讯作者在Nature Neuroscience, Neuron,Biological Psychiatry, PNAS, Cell Reports, The Journal of Neuroscience, Clinical Cancer Research,Cell Death and Disease, JBC, Chemistry,Chem. Biol. Drug Des.等杂志上发表多篇研究论文。

主持人才、科研基金、以及获奖情况

l国家自然科学基金 器官衰老与器官退行性变化重大研究计划-重点项目,胰岛素抵抗诱导神经元衰老及在老年痴呆发生发展中的作用、91849205,2019/01-2022/12,200万

l国家杰出青年科学基金,阿尔茨海默病的分子机制研究,81925010,2020/01-2024/12,400万

l国家自然科学基金 促进海峡两岸科技合作基金 重点项目,CDK3调控阿尔茨海默病中神经元死亡的机制及干预研究,U1905207,2020/01-2023/12,270万。

l国家自然科学优秀青年基金,81522016、阿尔茨海默病的致病机制研究、2016/01-2018/12,130万

l教育部“新世纪优秀人才”,50万NCET-13-0508

l福建省“高等学校新世纪优秀人才”,30万

l福建省杰出青年科学基金,2014J06019、老年痴呆疾病中Cdk5调控因子P35和P25的神经功能差异研究、30万。

l国家自然科学基金面上项目,81271421、阿尔茨海默病中CDK5对神经元细胞周期紊乱的作用和机制研究、70万

l国家自然科学基金面上项目,31571055、Cdk5磷酸化Bag3及其在神经元突触功能和凋亡中的作用与机制研究,64万

l福建省卫生教育联合攻关计划,40万

l横向课题,“肌醇生物功效的深入开发研究”、200万

l厦门大学校长基金、团队基金、交叉基金(250万)

l2016-2019,国家重点研发计划2016YFC1305900

代表性文章:

1.Jiechao Zhou, Hei-Man Chow, Yan Liu, Di Wu, Meng Shi, Jieyin Li, Lei Wen, Yuehong Gao, Guimiao Chen, Kai Zhuang, Hui Lin, Guanyun Zhang, Wenting Xie, Huifang Li, Lige Leng, Mengdan Wang, Naizhen Zheng, Hao Sun, Yingjun Zhao, Yunwu Zhang, Maoqiang Xue, Timothy Y. Huang, Guojun Bu, Huaxi Xu, Zengqiang Yuan, Karl Herrup, Jie Zhang* CDK5-dependent BAG3 degradation modulates synaptic protein turnover. Biological Psychiatry. 2020, 87(8):756-769.

2.Hei-man Chow, Meng Shi, Aifang Cheng, Yuehong Gao, Guimiao Chen, Xuan Song, Raphaella Wai Lam So, Jie Zhang*, Karl Herrup*Age-related hyperinsulinemia leads to insulin resistance in neurons and cell-cycle-induced senescence. Nature Neuroscience. 2019, 22(11):1806-1819.

3.Fuqiang Wang, Wenxing Zhao, Yuehong Gao, Jiechao Zhou, Huifang Li, Guangyun Zhang, Dong Guo, Chengrong Xie, Jie Li, Zhenyu Yin*, Jie Zhang*. CDK5-mediated phosphorylation and stabilization of TPX2 promotes hepatocellular tumorigenesis. J Exp Clin Cancer Res. 2019, 38(1):286.

4.Lige Leng, Kai Zhuang, Zeyue Liu, Changquan Huang, Yuehong Gao, Guimiao Chen, Hui Lin, Yu Hu, Di Wu, Meng Shi, Wenting Xie, Hao Sun, Zhicheng Shao, Huifang Li, Kunkun Zhang, Wei Mo, Timothy Y. Huang, Maoqiang Xue, Zengqiang Yuan, Xia Zhang, Guojun Bu, Huaxi Xu, Qi Xu,* and Jie Zhang* Menin Deficiency Leads to Depressive-like Behaviors in Mice by Modulating Astrocyte-Mediated Neuroinflammation. Neuron 2018, 100(3):551-563

5.Kai Zhuang, Changquan Huang, Lige Leng, Honghua Zheng, Yuehong Gao, Guimiao Chen, Zhilin Ji, Hao Sun, Yu Hu, Di Wu, Meng Shi, Huifang Li, Yingjun Zhao, Yunwu Zhang, Maoqiang Xue, Guojun Bu, Timothy Y. Huang, Huaxi Xu, Jie Zhang* Neuron-specific menin deletion leads to synaptic dysfunction and cognitive impairment by modulating p35 expression. Cell Reports 2018, 24, 701–712

6.Dong Guo, Wenting Xie, Pan Xiong, Huifang Li, Siqi Wang, Guimiao Chen, Yuehong Gao, Jiechao Zhou, Yun-wu Zhang, Guojun Bu, Maoqiang Xue*, Jie Zhang* Cyclin-dependent kinase 5-mediated phosphorylation of chloride intracellular channel 4 promotes oxidative stress-induced neuronal death. Cell Death Dis. 2018, 9(10):951.

7.Jiechao Zhou, Huifang Li, Xiaoping Li, Guanyun Zhang, Yaqiong Niu, Zengqiang Yuan, Karl Herrup, YunWu Zhang, Guojun Bu, Huaxi Xu, Jie Zhang* The Roles of Cdk5-Mediated Subcellular Localization of FOXO1 in Neuronal Death. The Journal of Neuroscience 2015, 35(6):2624-2635

8.Longlong Cao, Jiechao Zhou, Junrong Zhang, Sijin Wu, Xintao Yang, Xin Zhao, Huifang Li, Ming Luo, Qian Yu, Jianwei Xie, Ping Li, Xiaoqing Hu, Chaohui Zheng, Guojun Bu, Yun-wu Zhang, Huaxi Xu*, Yongliang Yang*, Changming Huang*, Jie Zhang* Cyclin dependent kinase 5 decreases in gastric cancer and its nuclear accumulation suppresses gastric tumorigenesis. Clinical Cancer Research 2015, 21(6):1419-1428

9.Hei-man Chow, Dong Guo, Jiechao Zhou, Gunagyun Zhang, Huifang Li, Karl Herrup, Jie Zhang*. CDK5 activator protein p25 preferentially binds and activates GSK3β. Proc Natl Acad Sci (USA). 2014, 111(45):E4887-4895

10.Mingshan Niu, Jin Hu, Sijin Wu, Xiaoe Zhang, Huaxi Xu, Yunwu Zhang, Jie Zhang*, Yongliang Yang * Structural Bioinformatics-Based Identification of EGFR Inhibitor Gefitinib as a Putative Lead Compound for BACE. Chem. Biol. Drug Des. 2014, 83(1):81-88.

11.Jie Zhang*, Huifang Li, Tingwen Zhou, Jiechao Zhou, Karl Herrup*. Cdk5 levels oscillate during the neuronal cell cycle: Cdh1 ubiquitination triggers proteosome-dependent degradation during S-phase, J Biol. Chem. 2012, 287(31): 25985-25994

12.Jie Zhang, Karl Herrup*, Nucleocytoplasmic Cdk5 is involved in neuronal cell cycle and death in post-mitotic neurons. Cell Cycle 2011, 10(8): 1208-1214

13.Jie Zhang, Huifang Li, Karl Herrup*. Cdk5 suppresses the neuronal cell cycle by disrupting the E2F1-DP1 complex. The Journal of Neuroscience 2010, 30:5219-5228

14.Jie Zhang, Huifang Li, Karl Herrup*. Cdk5 nuclear localization is p27-dependent in nerve cells: implications for cell cycle suppression and caspase-3 activation, J. Biol. Chem. 2010, 285(18): 14052-14061

15.Jie Zhang, Samantha Cicero, Li Wang, Romito-Digiacomo, R.R., Yan, Yang, Karl Herrup* Nuclear localization of Cdk5 is a key determinant in the post-mitotic state of neurons. Proc. Nat. Acad. Sci. (USA) 2008, 105: 8772-8777

16.Jie Zhang, Karl Herrup. Cdk5 and the non-catalytic arrest of the neuronal cell cycle, Cell Cycle 2008, 7:3487-3490

17.Qiang Liu#, Jie Zhang#, Hua Zhu, Chuna Qin, Qi Chen, Baolu Zhao*, Dissecting the signaling pathway of nicotine-mediated Nneuroprotection in amouse Alzheimer disease model. FASEB J. 2007, 21(1): 61-73(#Equal contribution)

18.Jie Zhang, Qiang Liu, Nian-Qing Liu, Fu-Liang Li, Qi Chen, Chuan Qin, Hua Zhu, Yu-Ying Huang, Wei He, Bao-Lu Zhao*, Nicotine attenuates beta-amyloid-induced neurotoxicity by regulating metal homeostasis. FASEB J. 2006, 20(8):1212-1224

19.Jie Zhang, Xue-Fei Wang, Zhong-Bing Lu, Nian-Qing Liu, Bao-Lu Zhao, The effects of meso-2, 3-dimercaptosuccinic acid and oligomeric procyanidins on acute lead neurotoxicity in rat hippocampus. Free Radic. Biol. Med. 2004, 37:1037-1050

20.Li Wang, Jie Zhang, Karl Herrup Cdk5 may be an atypical kinase, but not in the way you think, Cdk5 book, Ip, N. and Tsai, L-H, eds., Springer.

社会兼职:

中国神经科学学会神经內稳态和内分泌分会副主任委员

中国生物物理学会自由基生物学与医学专业委员会常务理事

Pharmacological Research, Consulting Editor