专家

栉风沐雨,八十五载守护健康。

许韧

科室:职称:医学博士后、教授、博士生导师

擅长:

许韧

医学博士后、教授、博士生导师,细胞应激生物学国家重点实验室课题组长,“闽江学者”特聘教授,国际华人骨研学会终身会员、美国和日本骨代谢学会会员、获得中国驻日本大使馆-中国学友会会长荣誉证书、日本文部省(教育部) 全球杰出计划-“超级学生” 称号、国际华人骨研学会(ICMRS)Webster Jee青年学者奖、国际骨免疫年会-青年学者奖、美国骨代谢研究学会(ASBMR)青年学者奖、美国骨研究促进会(AIMM)John Haddad青年学者奖、厦门大学“南强青年拔尖人才”-A类、中组部青年千人-会评(新冠疫情延期中)。近年来,骨骼系统与机体其他组织/器官之间的偶联机制逐渐成为系统生物学研究的新兴热点,也是进行精准医学治疗所必须明确的核心内容。许韧博士一直聚焦于骨形成细胞与其支撑系统的交流机制,深入探究成骨微环境的调控功能和潜在的临床价值。其中以第一作者身份在NatureNature MedicineJBMR等国际知名期刊上均发表研究成果。

目前实验室致力的主要研究方向如下:

1)骨特异性神经/血管体系在骨骼退行性疾病中的作用机制

2)成骨细胞来源细胞因子在机体能量代谢中的功能

3)骨骼干细胞/前体细胞在癌症发生和骨转移中的介导机制

主持科研项目

1. 国家自然科学基金面上项目(8197090543),2020/01-2023/12,SLIT3介导的血管亚型在骨骼干细胞微环境中的作用机制研究,¥550,000,主持

2.厦门大学“南强青年拔尖A类人才”启动经费,¥3,000,000,主持

3.CornellUniversity-FFPI Grant, “Identification of Novel Mediators Governing Osteoblast-Type H Endothelial Cells Coupling”, 2015-2017,$100,000,主持.

已申请的专利:

美国专利:Matthew Greenblatt,Ren Xu and Laurie Glimcher, SLIT and Bone Growth Modulation (Filing, US 62/630,557) 2018

主要相关论著:

1.Li N, InoueK, Sun J, Niu Y, Lalani S, Yallowitz A, Yang X, Zhang C, Shen R, Zhao B,Xu R#, Greenblatt MB. Osteoclasts Are Not a Source of SLIT3. Bone Res. 2019 .

2.Ji G*,Xu R*, Niu Y, Li N, Ivashkiv L, Bostrom MPG, Greenblatt MB, Yang X. Vascular endothelial growth factor pathway promotes osseointegration and CD31(hi)EMCN(hi) endothelium expansion in a mouse tibial implant model: an animal study.Bone Joint J. 2019 Jul;101-B:108-114.

3.Xu R, Yallowitz A, Qin A, Wu Z, Shin D, Kim J, Debnath S, Ji G, Bostrom M, Yang X, Zhang C, Dong H, Kermani P, Lalani S, Li N, Liu Y, Poulos M, Wach A, Zhang Y, Inoue K, Lorenzo A, Zhao B, Butler J, Shim J, Glimcher L and Greenblatt MB. Targeting skeletal endothelium to ameliorate bone loss.Nature Medicine 2018 Jun;24(6):823-833.

4.Debnath S, Yallowitz A, McCormick J, Lalani S, Zhang T,Xu R, Li N, Liu Y, Yang Y, Eiseman M, Shim J, Hameed M, Healey J, Bostrom M, Landau D, Greenblatt MB. Discovery of a periosteal stem cell mediating intramembranous bone formation and fracture healing.Nature 2018 Oct;562(7725):133-139.

5. Inoue K, Deng Z, Chen Y, Giannopoulou E,Xu R, Gong S, Greenblatt MB, Mangala LS, Lopez-Berestein G, Kirsch DG, Sood AK, Zhao L, Zhao B. Bone protection by inhibition of microRNA-182.Nat Commun. 2018 Oct 5;9(1):4108.

6.Ji G, Han A, Hao X, Li N,Xu R, Wang F. Better rotational control but similar outcomes with the outside-in versus the transtibial drilling technique foranterior cruciate ligament reconstruction: a systematic review of comparativetrials.Arch Orthop Trauma Surg. 2018 Nov;138(11):1575-1581.

7.Xu R, Zhang C, Shin DY, Kim JM, Lalani S, Li N, Yang YS, Liu Y, Eiseman M,Davis RJ, Shim JH, Greenblatt MB. c-Jun N-terminal kinases (JNKs) are criticalmediators of osteoblast activity in vivo.J Bone Miner Res. 2017 Sep;32(9):1811-1815.

8.Ma C, Fukuda T, Ochi H, Sunamura S, Xu C,Xu R, Okawa A, Takeda S. Genetic determination of the cellular basis of the ghrelin-dependent bone remodeling.Mol Metab. 2015 Jan 21;4(3):175-85.

9.Xu R#. Semaphorin 3A: A new player in bone remodeling.Cell Adh Migr. 2014;8(1):5-10. Review.

10.Fukuda T*, Takeda S*,Xu R*, Ochi H, Sunamura S, Sato T, Shibata S, Yoshida Y, Gu Z, Kimura A, Ma C, Xu C, Bando W, Fujita K, Shinomiya K, Hirai T, Asou Y, Enomoto M, Okano H, Okawa A, Itoh H. Sema3A regulates bone-mass accrual through sensory innervations.Nature 2013 May 23;497(7450):490-3.

11.Wang M, Liu S, Li Y,Xu R, Lu C, Shen Y. Protoplast mutation and genome shuffling induce the endophytic fungusTubercularia sp. TF5 to produce new compounds.Curr Microbiol. 2010 Oct;61(4):254-60.

12. Inose H, Ochi H, Kimura A, Fujita K,Xu R, Sato S, Iwasaki M, Sunamura S, Takeuchi Y, Fukumoto S, Saito K, Nakamura T, Siomi H, Ito H, Arai Y, Shinomiya K,Takeda S. A microRNA regulatory mechanism of osteoblast differentiation.Proc Natl Acad Sci U S A. 2009 Dec 8;106(49):20794-9.

13.Xu R, Wang M, Lu C, Shen Y. Tuberculariol A – C, new sesquiterpenes from mutant-741 ofTubercularia sp. TF5.Helv Chim Acta. 2009;92:1514-19.

14.Xu R, Lu C, Wu X, Lin C and Zheng Z. A new ten-membered lactone fromTubercularia sp. TF5, an endophytic fungus ofTaxus mairei.Chem. Nat. Compd. 2009;45; 6.

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